2001. 982 pp. This volume looks at how humans respond acutely to, and sometimes fail to adapt to high altitude (2000-8850 metres), in particular to the hypoxia of high altitude. The book is divided into four parts: The Stage looks at the history of human enquiry into our existence at high altitude, the nature of the atmosphere and how it came to be, and gives an anthropological perspective on those living permanently at great heights. The second part, Organism defence, explores how cells within the body detect that the oxygen they need is in short supply and how they defend themselves against stress. Part four, Oxygen's journey from air to mitochondrion, looks at the movement of oxygen by the pulmonary and blood circulatory systems.. The last part, Maladaptation, describes failure to thrive at high altitude: mountain sickness and the challenge of lowland dwellers with pre-existing medical conditions who travel to high altitudes.
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Description
This book explores how humans respond to the hypoxia of high altitudes, addressing the response of lowlanders to sudden and sustained exposure, as well as that of those living permanently at high elevations. Examines adaptation and maladaptation, acute and chronic high-altitude illnesses, and the challenges faced by lowland dwellers with preexisting medical conditions who venture to high altitude! Containing more than 3000 references and over 200 tables, charts, and graphs that support the text, High Altitude
offers an anthropological perspective on those who dwell permanently at great heights
investigates how cells sense oxygen, including arterial chemoreceptors, erythropoietin-producing tissues, and pulmonary vascular smooth muscle
discusses the role of individual organs as well as their integrated function in enabling physical and mental performance at high altitude
focuses on the additional metabolic and circulatory demands of perception, thought, and action in the brain
considers how organisms defend themselves against the stress of hypoxia
and more!
Written by more than 55 contributors who are among the world’s leading authorities and investigators, High Altitude is a provocative referencefor pulmonologists, physiologists, biologists, critical care specialists, internists, primary care physicians, pediatricians, and medical school students.
Return to TopTable of Contents
The Growth of Knowledge About Air, Breathing, and Circulation as They Relate to High Altitude Charles S. Houston The Atmosphere John B. West The People Susan Niermeyer, Stacy Zamudio, and Lorna G. Moore Cellular and Molecular Mechanisms of O2 Sensing with Special Reference to the Carotid Body Sukhamay Lahiri and Neil S. Cherniack Molecular/Metabolic Defense and Rescue Mechanisms for Surviving Oxygen Lack: From Genes to Pathways Peter W. Hochachka Control of Breathing at High Altitude Curtis A. Smith, Jerome A. Dempsey, and Thomas F. Hornbein Mechanics of Breathing Joseph Milic-Emili, Bengt Kayser, and Henry Gautier Gas Exchange Peter D. Wagner The Cardiovascular System at High Altitude: Heart and Systemic Circulation Eugene E. Wolfel and Benjamin D. Levine The Pulmonary Circulation at High Altitude John T. Reeves and Kurt R. Stenmark Cerebral Circulation at High Altitude John W. Severinghaus The High-Altitude Brain Marcus E. Raichle and Thomas F. Hornbein Autonomic Nervous System Douglas R. Seals, Pamela Parker Jones, and Kevin P. Davy The Effects of Altitude on Skeletal Muscle Howard J. Green and John R. Sutton Blood Robert F. Grover and Peter Bärtsch Renal Function and Fluid Homeostasis Erik R. Swenson Metabolic Responses of Lowlanders to High-Altitude Exposure: Malnutrition Versus the Effect of Hypoxia George A. Brooks and Gail E. Butterfield The Endocrine System Jean-Paul Richalet High Altitude and Human Immune Responsiveness Richard T. Meehan, Peter N. Uchakin, and Clarence F. Sams Exercise and Hypoxia: Performance, Limits, and Training Robert Roach and Bengt Kayser Sleep John V. Weil and David P. White Acute Mountain Sickness and High-Altitude Cerebral Edema Peter Bärtsch, Robert. Roach, and Diana Depla High-Altitude Pulmonary Edema Robert B. Schoene, Herbert N. Hultgren, and Erik R. Swenson Chronic Mountain Sickness in Andeans Carlos C. Monge, Fabiola Léon-Velarde, and Alberto Arregui High Altitude and Common Medical Conditions Peter H. Hackett
